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当前位置: 首页 > 产品中心 > > Echelon/MG-115 (Proteasome Inhibitor)/5 mg/882-10 5mg
商品详细Echelon/MG-115 (Proteasome Inhibitor)/5 mg/882-10 5mg
Echelon/MG-115 (Proteasome Inhibitor)/5 mg/882-10 5mg
Echelon/MG-115 (Proteasome Inhibitor)/5 mg/882-10 5mg
商品编号: 882-10 5mg
市场价: ¥3160.00
美元价: 1580.00
产地: 美国(厂家直采)
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产品分类: 其他
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商品介绍

CAS Number: 133407-86-0Molecular Weight: 461.29Salt Form: N/APurity: >96%Sequence (3-letter): Z-Leu-Leu-Nva-CHOSequence (1-letter): Z-LL(Nva)-CHOStorage: -20 °C or below

MG-115 (Z-Leu-Leu-Nva-CHO) is a potent, cell permeable inhibitor of the 20S proteosome. It forms a reversible hemiacetal adduct and can also inhibit cathepsins and calpains. It reduces degradation of ubiquitinated proteins and blocks proteolytic conversion of protein precursors. MG-115 is known to induce the heat shock response and apoptosis.

References

Rock, K.L., Gramm, C., Rothstein, L., et al. (1994) “Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules”. Cell 78, 761-771.

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